Trouble or not, e5 has at the very least secured impressive media buzz from the Min and Wolff appointments, not to mention Beckman himself, who left a president and chief executive post at Condé Nast’s Fairchild Fashion Group in January to head up e5.e5 Global Media, backed by Pluribus Capital Management and Guggenheim Partners, bought the Adweek Media Group titles, along with The Hollywood Reporter and four other brands from Nielsen Business Media in late 2009. Michael Wolff, Newser founder and Vanity Fair columnist, has been named editorial director of Adweek Media, a group of trade magazines including Adweek, Mediaweek and Brandweek owned by e5 Global Media. Wolff is the second high-profile appointment since e5 CEO Richard Beckman hired Janice Min as editorial director of The Hollywood Reporter. Wolff [pictured] is known for his aggressive take on the media business and it appears that this sensibility was key to his appointment and one he will continue to exploit. Beckman told the New York Times that Wolff is “…controversial. Which is good. If you want to make an omelet you have to break some eggs.”Likewise, Wolff said of his hire that he plans on having a lot of fun covering the media business and that he wants to “make some trouble.”
Intel’s stunning Twin Rivers and Honeycomb Glacier concept laptops reading • Computex 2019: Every announcement you need to know Next week the tech world will converge in San Francisco for WWDC, Apple’s conference on all things iOS and Mac. But for the past week in Taipei, Taiwan for Computex, we’ve gotten a glimpse into the future of Windows PCs and laptops.The big, long-term takeaway is that single-screen laptops are possibly a thing of the past — or dual-screen laptops are going to be the tech industry’s next spectacular gimmick. Either way, there will be many multiple-screen devices in our future.The chip business is also, ahem, heating up. AMD had a buzz-creating showing at Computex, while Intel introduced its 10th-generation Ice Lake CPUs, among other big announcements. Qualcomm, meanwhile, promises 5G laptops in the not-too-distant future, and Nvidia is expanding its graphics card line to better accomodate creatives.And then there were the cases. Oh, the cases. Here’s a breakdown of everything you need to know. 17 Photos See All The outrageous computer cases of Computex 2019 9 Photos Now playing: Watch this: And that’s just the beginning, Intel saysAs nifty as Asus’ ZenBook Pro Duo looks, it could be just the first step to a dual-screen future. Intel at Computex showed off two concept laptops, Twin Rivers and Honeycomb Glacier, to demonstrate what it thinks our laptops will look like in the coming years. (Remember, Intel doesn’t make computers, just computer parts, so these are just demonstrations to show what can be made off the back of Intel tech.)Twin Rivers is Intel’s take on thin-and-light, ultra-portable laptops. It’s a dual 12.3-inch display setup, where the bottom screen has an onscreen keyboard, like one you’d find on a tablet. However, this concept also comes with a physical Bluetooth keyboard that fits perfectly atop the virtual one for use in long sessions. Then there’s Honeycomb Glacier. It’s a gaming rig, with a 17.3-inch main display and a 12.3-inch secondary screen. It’s similar to the ZenBook Pro Duo, except that it has an ergonomic lift that lets you game with less shoulder-hunching action. Tags May 29 • The outrageous computer cases of Computex 2019 23 Photos 1 Asus doubles down on dual displaysAsus unveiled the ZenBook Pro 15 at last year’s show. Its star feature was the ScreenPad, a phone-sized second screen that functioned as the laptop’s trackpad. One year later, Asus’ ZenBook Pro Duo became Computex 2019’s star product.In addition to its 15-inch 4K main display, the ZenBook Pro Duo has a 14-inch screen above its keyboard. It’s the same length and resolution as the top screen, but about half as deep. It can serve two different functions: you can either use it as an extension of the main stream, so for instance your Facebook feed will flow from one screen down to the second, or as a completely separate display.The latter option allows you to run three programs on the bottom screen. So, you may be doing your work on the main display and have Spotify, Facebook Messenger and Netflix open on the bottom three. (In which case, you’re probably not getting much work done.)Apart from that, it’s an impressively spec’d high-end laptop. It can be configured with up to an Intel Core i9 CPU and an Nvidia RTX 2060 GPU. There’s also a less expensive version, the ZenBook Duo, that goes up to a Core i7 and an Nvidia MX250 card. The sacrifice here is weight: It’s not chunky like a gaming laptop, but it’s not a thin-and-light device either. Asus is calling the big second screen a ScreenPad Plus. The regular ScreenPad in last year’s ZenBook Pro 15, now called the ScreenPad 2 thanks to improvements in responsiveness and functionality, will be ported to Asus’ less expensive ZenBook line and its less expensive still VivoBook S range. May 29 • The laptops of tomorrow will make us even more productive — and it’s terrifying Share your voice • Computex 2019 Laptops Gaming Asus ZenBook Pro Duo foreshadows our multiscreen future Alienware m15, m17 get a bold new look 2:17 But Intel had a strong showing at Computex, too. Apart from the dazzling concepts shown above, Intel’s two main announcements were its 10th-gen Ice Lake CPUs and Project Athena.While AMD focused on benchmark comparisons, Intel promised tangible quality-of-life improvements. Laptops with its Ice Lake chips will be even thinner than already lithe devices like the Dell XPS and HP Envy and their battery life will be improved, too. I was personally most impressed by Ice Lake’s gaming chops: Intel showed an Ice Lake-powered laptop running Destiny 2 on integrated graphics alone, without any discrete GPU.Project Athena, meanwhile, is a new class of laptop. To get the Athena stamp of approval, companies like Asus, Lenovo and Dell need to make laptops that hit certain criteria. These include the ability to wake up within a second, achieve 9 hours of “real-world battery life” and more. Project Athena laptops will hit the market by the end of the year, Intel says.Qualcomm made a similar pitch. Just as its parts power the 5G phones from Samsung, LG and Nokia, the American company wants to fuel the 5G laptop revolution. It says we’ll soon have laptops that are internet connected at all times and location aware — in addition to the usual promises of svelter designs and longer battery lives.Nvidia unveiled RTX Studio, which are laptops powered by its new Quadros RTX GPUs. These graphics cards have similar power to the new RTX GeForce cards (that is to say, a lot), but have much more memory. A high-end GeForce GPU will have 8GB of memory, for instance, while Quadro cards can double that. The average Joe won’t need that boost, but for creatives who work with 3D rendering and high-resolution video editing (think 4K, 6K and 8K), it makes a huge difference.And finally, UK-based Arm announced its Cortex-A77 chip, which it promises will make high-end Android phones 20% faster in 2020.The laptops of ComputexThe Asus ZenBook Pro Duo was the most attention-grabbing laptop at Computex, but it wasn’t the only one worth your attention. Dell pushed meaningful updates to both its premium productivity laptop, the XPS, and its premium gaming laptop, the Alienware m. The XPS 15 gets OLED displays for the first time, as well as Intel’s Ice Lake CPU, Nvidia’s GTX 1650 and 64GB of RAM. The Alienware m15 and m17 laptops got significant facelifts, and the latter can now be configured with a 244Hz display. By the way, if you prefer hulking gaming laptops over thin-and-light-but-less-powerful ones, check out MSI’s newest Titan. It has an RTX 2080 — no Max-Q tweaking needed. The most futuristic feature of this laptop, however, is eye tracking. In the demo we saw the laptop had four windows open, one on the main screen and three on the bottom one. The laptop tracked the demonstrator’s eyes and put him in control at whatever window he was looking at, distinguishing even between the three on the bottom screen. It was wild.Intel says we’ll see devices like Twin Rivers in “one to two years.” However, it gave no timeline on when a Honeycomb Glacier-like gaming rig would hit the market.Processor proselytismOne of Computex’s biggest stories wasn’t about devices, but the parts that power them. Intel and Nvidia have both dominated the CPU and GPU markets, respectively, for the past decade. Since 2015, Intel has held roughly 80 percent of the processor market against its main rival, AMD. Meanwhile, Nvidia has fluctuated from 60 to 80% over its main rival, AMD.But AMD, whose CPU marketshare has jumped 3% in the last year, came out guns blazing at Computex. It officially announced its Navi range of Radeon GPUs, which will power the Sony PlayStation 5, but its main focus was on competing with Intel. The “one last thing” moment of the press conference was the Ryzen 7 3900X CPU. A competitor for Intel’s top-of-the-line Core i9 9920X CPU, the “no compromise” Ryzen 7 3900X features 12 cores and has a boost clock speed of 4.6GHz. It runs on 105 watts, versus the 9920X’s less efficient 165 watts, and more importantly will retail for $499 upon its July 7 release. The 9920X, for comparison, costs $1,199.Notably, AMD stock rose 10% after the announcement. 40 Photos May 30 • Alienware redesigns its thin gaming laptops and offers OLED Comment Luxury trimmings were also displayed at Computex, with Asus revealing a special 30th-anniversary edition of the ZenBook. A 13-inch, ScreenPad-equipped laptop clad in genuine white leather and 18 karat rose gold plating. Then there’s HP’s updated Envy, which comes with a wooden palm rest.Last but not least, Nvidia’s RTX Studio parts are cool — but mean nothing without companies making laptops for creatives. Razer and Acer have stepped up to the plate, with the former committing its Razer Pro 17 to the RTX Studio program and Acer updating its ConceptD with new Quadro parts.And that’s it for Computex 2019! We’ll see you again next year, where we will presumably welcome our new 5G, tri-screened overlords. Computex 2019 Asus ZenBook Pro Duo doubles down on screens 5G Acer Asus Dell HP Intel Lenovo LG Nokia Nvidia Razer Samsung Sony Apple
Were celebs on drugs at Karan Johar’s party?Video screengrabFilmmaker Karan Johar has finally broken his silence over allegations of hosting a drug party for a few A-list Bollywood stars at his residence last month.In a recent interview, Karan is furious with the brouhaha around the alleged ‘drug party’, and says all such charges are “baseless and ridiculous”.It was an “easy night out”, the filmmaker says, adding that his mother was also appalled reading about it.”I toyed with the idea of giving out a statement. I toyed with giving out a thought on the social media about something… There were achieving members of the industry who were having an easy night out after a hard week of work, having a good time. I took that video with all the earnestness… would I be putting out that video if there was anything happening at all, I am not stupid,” he said in an interview with Rajeev Masand.Last month, Karan had posted a video on Instagram of a party he hosted at home. Soon afterwards, Akali Dal MLA Manjinder Singh Sirsa shared the video, alleging that top stars who were present at the party — such as Deepika Padukone, Ranbir Kapoor, Shahid Kapoor, Varun Dhawan, Arjun Kapoor, Malaika Arora, and Vicky Kaushal — were flaunting a “drugged look” in the video. He tagged the video with #UdtaBollywood, taking off on the film “Udta Punjab”, which was about the drug menace in the state of Punjab and which, incidentally, starred Shahid.Karan has now opened up on how the reflection of a light near Vicky was misconstrued as proof.”Apparently you are not allowed to scratch your nose. Apparently, you are not allowed to put your phone in your back pocket. Apparently, a shadow of light is perceived to be some kind of powder,” he said, further revealing that Vicky was recovering from dengue and was drinking hot water with lemon.”Some of us were chatting and some of us were having wine, but that was it. It was a baseless accusation, and it really annoyed me because you are taking away the culture and tradition that I have been raised in. My mother was appalled when she read those things because she was there. Which powder? We are all very committed professionals,” he said.The filmmaker called it a night out where friends were letting their hair down.”My mother, five minutes before this video, was sitting with us. It was that kind of a family, happy, social gathering, where friends were sitting and having a good time and we were listening to some music, having some good food and having good conversational energy there. There was nothing else going on,” he said.”The reason I didn’t put it out was because ‘why do I need to justify a house party which was a casual get together with good friends?’ How dare you grab it away from us? How dare somebody constantly make us soft target? It is ridiculous that someone can start spotting these things,” Karan said.He also said that his friends, who were present in the video, also found the accusations ridiculous.”I thought if I justify it will start looking that I am speaking too much in defense.”While he didn’t react to these accusations, he has decided that he will take a legal action next time.”I am not taking this very kindly, the next time where baseless accusations, I will take the legal route. You cannot mar our solid reputations, our sincere reputations our committed reputations just because you are presuming something. You cannot put out a baseless accusation that has no base, no fact, no truth, no reality and try and mar us and our reputations, it’s ridiculous.”The incident, he claimed, has left an impact on his mind.”I am, now, afraid to call up people to my home thinking that they might be afraid to show up,” he said.
A female student injured in the BCL attack being taken to hospital. Photo: Shahidul Islam/Prothom AloThe authorities have closed Rajshahi Institute of Health Technology (IHT) for an indefinite period to avoid untoward incident following an attack of Bangladesh Chhatra League (BCL) activists on female students.BCL is the student wing of ruling Bangladesh Awami League (AL).The authorities asked the institue’s male students to vacate its dormitories by 1:00pm and female students by 3:00pm.Female students alleged that a group of BCL activists entered the female dormitory and hurled abusive words at female students on 3 December as some of them could not turn up at a programme of the Medical Technologists held on the campus on the day.The female students of the institute on Wednesday morning went to the principal office to lodge a complaint against the BCL activists. The principle then assured them of taking actions after investigation.When the female students were about to come out of the principal office, BCL activists brought out a procession chanting slogans against them, frightening female students to return to their dormitories.At one stage, the principal of the institute himself escorted students to the dormitories.Students alleged BCL activists attacked some of them who fell behind while the principal was escorting them to the dormitory, leaving five female students injured.A police man trying to pacifying a BCL activist who was attempting to attack female students on Wednesday. Photo: Shahidul Islam/Prothom Alo The BCL activists launched the attack even in presence of the principal and the police. And police took no action, alleged the students.BCL, however, denied the allegation and the principal echoed it.BCL’s IHT unit president Zahidul Islam claimed that female students got frightened when BCL activists chased certain Mizan, who he claimed is a mentally retarded ex-student of the institute, after Mizan chanted slogans against BCL.“And some of the female students fell sick. Attacks were not launched on them and it will be proved in medical certificates,” he claimed.Later, the academic council of the institute sat for an emergency meeting and decided to close the institution for an indefinite period to fend off any unwanted situation.When approached, institute principal Sirazul Islam said, “BCL did not launch attacks on female students. Some of female students sustained injuries while hastily entering the dormitory.”
Firefighters on ladders work to extinguish a blaze in an office building in Dhaka on 28 March 2019. Photo: AFPAn electric short-circuit on the eighth floor of FR Tower sparked the deadly fire that killed 26 people last month, state minister for disaster management Enamur Rahman said Tuesday.”The fire spread to the ninth and 10th floors. A number of people died because of smoke in the 11th, 12th and 13th floors,” he said after meeting the ministry’s probe committee and representatives of various ministries, reports UNB.Enamur admitted that the fire service and civil defence lacks equipment.”We wanted to procure equipment worth Tk 10 billion but after Churihatta and FR Tower fires, we understood that this budget is insufficient,” he said.Seventy-one people were killed after a deadly blaze swept through several buildings in the old quarter of Dhaka in late February.Many of the capital’s buildings are unplanned and lack proper firefighting equipment.”We’ve realised that we need heavy machinery and a bigger budget to ensure fire extinguishing system,” the state minister added.
(Phys.org)—A team of researchers with the University of Georgia in Athens has developed a technique for controlling chemical reactions that release drugs inside the body. In their paper published in the journal Nature Catalysis, the group describes coating chemicals to prevent a reaction from occurring until the application of a magnetic field that releases a desired drug. In some medical applications, it is better for a medical treatment if a chemical can be applied directly to a certain part of the body and nowhere else. Chemicals meant to treat tumors are the prime example—chemotherapy drugs act on every cell they contact, causing a host of negative side effects. In this new effort, the group took a novel approach to solving this problem, using a magnet to force coated chemicals together, prompting a drug releasing reaction.To provide a means for controlling when chemicals come into contact inside the body, the researchers created tiny packets by first coating iron oxide nanoparticles with silica and then coating them further with two types of polymers, which, when combined, form a brush-like structure. Each of the packets was then loaded with either an enzyme or a substrate meant to react with the enzyme, and, of course, the drug to be released. In practice, the packets would be released into the body of a patient, where they would make their way to the whole body, behaving harmlessly, as the brushes prevent them from reacting whenever they meet. When the packets made their way to a site where a reaction was wanted, the researcher applied a magnet that forced them close together—close enough that they could react, releasing the drug. The other packets not involved in the reaction would slowly be flushed out of the body naturally, without causing harm.The researchers tested their packets in vitro using a real chemotherapy drug and cancer cells. They report it worked just as they had envisioned. More testing is required, of course, to ensure the technique is safe, but if all goes well, it could eventually be used to treat a wide variety of cancers. Multi stimuli-responsive nanocapsules selectively deliver drugs to exactly where they are needed Journal information: Nature Catalysis Explore further E- and S-type superparamagnetic nanoparticles carrying the enzyme and the substrate. a,b, Cryo-transmission electron microscopy (cryo-TEM) image (a) and schematic (b) explaining the concept of the magnetic-field-triggered biocatalysis. The particle superparamagnetic core is made of Fe3O4 nanoparticles enveloped by silica. The silica envelope is labelled with covalently bound fluorescent dyes (red for E-particles and green for S-particles). In the magnetic field, due to dipole–dipole interactions, the particles are brought into contact, so that the brush-like double-layer shells merge and intertwine, enabling interactions between the enzyme and substrate. The inner layers of the brush-shell are made of polyacrylic acid (PAA), which carries conjugated molecules of enzymes and substrates and provides the acidic environment for hydrolytic reactions. The external shell of poly(ethylene glycol methyl ether acrylate) polymer (PPEGMA) secures a barrier function to block ‘unauthorized’ or premature reactions of the enzyme and the substrate. The biocatalytic reaction is localized within the biocatalytic nanocompartment, which is generated in the magnetic field. The reaction is monitored by detecting the released cargo molecules. Credit: (c) Nature Catalysis (2017). DOI: 10.1038/s41929-017-0003-3 More information: Andrey Zakharchenko et al. Magnetic field remotely controlled selective biocatalysis, Nature Catalysis (2017). DOI: 10.1038/s41929-017-0003-3AbstractMany applications for medical therapy, biotechnology and biosensors rely on efficient delivery and release of active substances. Here, we demonstrate a platform that explores magnetic-field-responsive compartmentalization of biocatalytic reactions for well-controlled release of chemicals or biological materials on demand. This platform combines two different kinds of core–shell magnetic nanoparticle: one loaded with enzymes and another with substrate-bound therapeutic (bio)chemicals. Both cargos are shielded with a polymer brush structure of the nanoparticle shell, which prevents any enzyme–substrate interactions. The shield’s barrier is overcome when a relatively weak (a fraction of 1 T) external magnetic field is applied and the enzyme and the substrate are merged and forced to interact in the generated nanocompartment. The merged biocatalytic nanoparticles liberate the substrate-bound therapeutic drugs when the enzymes degrade the substrate. The developed platform provides a proof of concept for the remotely controlled release of drugs or (bio)chemicals using the energy of a non-invasive, weak magnetic field. © 2017 Phys.org Citation: Using magnets to control chemical reactions that target release of medicines inside the body (2017, November 21) retrieved 18 August 2019 from https://phys.org/news/2017-11-magnets-chemical-reactions-medicines-body.html This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
Kolkata: Metro services were disrupted for sometime in the peak hours of Monday evening after smoke was detected beneath a Dum Dum-bound non AC rake at MG Road Metro Station.The incident triggered panic among the passengers who were standing on the platform to catch a train. After the train entered the platform, the motor man spotted smoke billowing out from beneath the rake. The matter was immediately informed to the railway officials. The power connection in the third rail was immediately disconnected. Also Read – Rain batters Kolkata, cripples normal lifeThe Metro personnel and the RPF rushed to the spot and evacuated all the passengers.The train was taken to the car shed. According to the Metro railway officials, train services between Maidan and Girish Park remained suspended for sometime due to the incident.Truncated services were being operated between Dum Dum and Girish Park in the Up line and between Maidan and Kavi Subhash stations in the Down.Some of the passengers were who were stranded at Esplanade Metro Station alleged that there was utter chaos at the station as services were suspended for more than half an hour during peak hours. Also Read – Speeding Jaguar crashes into Mercedes car in Kolkata, 2 pedestrians killedHundreds of commuters, who entered the stations, that are situated between Maidan and Girish Park faced inconvenience due to the disruption. Many passengers took buses to reach home.The passengers alleged that things were not properly communicated to them about when would train services resume between Maidan and Girish Park.Metro authorities are yet to ascertain the cause of the smoke which might have triggered due to some technical glitches, officials suspect.A senior official of the Metro railways said the situation was brought under control within a few minutes. The train services soon resumed between Girish Park and Maidan stations. A probe has been initiated in this regard.